Amino acids are essential for the synthesis of energy and the construction of all the proteins in our body. But when it comes to amino acid supplements, such as mythoxan, distinctions need to be made because not all are the same.
The Mythoxan line is at the forefront and this is demonstrated by an article published in Science, one of the most important scientific journals in the world.
This article boasts the anti-aging properties of Alpha-ketoglutarate, a fundamental molecule of the Krebs cycle.
Unlike what is usually offered in the amino acid supplement market, the new Mythoxan line always contains a derivative called ornithine alpha-ketoglutarate.
What is it about?
Ornithine alpha-ketoglutarate is an AKG salt that has the main task of detoxifying the body from excess ammonia that is formed especially in extreme physical activity and in some liver and kidney diseases.
Ornithine alpha ketoglutarate stimulates GH production but is also a precursor of arginine, an amino acid known for its effects on tissue oxygenation, to improve endurance and recovery from fatigue. Alpha-ketoglutarate is nothing more than a transporter that enhances the effects of ornithine, favoring its assimilation and use.
So why not give Arginine directly?
Arginine must be synthesized starting from essential amino acids, never administer it from the outside to prevent an enzymatic process that inhibits its own synthesis.
As SCIENCE writes, bodybuilders use alpha-ketoglutarate to improve muscle trophism, but this molecule can offer far wider health benefits.
The study, “Bodybuilding supplement promotes healthy aging and extends life span, at least in mice” 2020, demonstrates how alpha ketoglutarate allows a significant extension of the duration and quality of life in animals taking the supplement compared to the control group .
Other compounds, such as the drugs rapamycin and metformin have shown similar effects but AKG, which is naturally produced by the body, is safer and more tolerated in the long term.
AKG is part of the metabolic cycle that our cells use to make energy from food but levels in the blood gradually decrease as we age. The scientists’ goal was to restore the levels to those seen in young animals. In the study, Gordon Lithgow and Brian Kennedy of the Buck Institute for Research on Aging gave groups of 18-month-old mice (about 55 years in human years) the equivalent of 2% of their daily food as AKG for 21 months.
Some differences popped up within a few months: “They looked much blacker, shinier, and younger” than the control mice, says Azar Asadi Shahmirzadi. Additionally, AKG-fed mice averaged over 40% higher in “frailty” tests, measured by 31 physiological attributes including hair color, hearing, gait, and grip strength.
By probing the mechanism of these improvements, the researchers found that female mice receiving AKG produced higher levels of an inflammation-reducing molecule. Chronic inflammation can stimulate many diseases of aging such as cancer, heart disease, arthritis and dementia.
doi: 10.1126/science.abe5953
