In our study and research activity, we often come across interviews and articles by scientists with common objectives to our way of acting and thinking. In recent days, I found Dr. Andrew Steele, a computational biologist in the Luscombe Lab of the Francis Crick Institute in London, who studies important topics such as longevity and health.
Dr. Steele says there will come a day when it will be possible to treat aging like any other disease. Many of your colleagues are incredulous or even hostile to your thesis, but their reaction depends on the fact that they have been accustomed to thinking of aging as an inevitable fact of life.
What if this is not the case?
“What do people mostly die of today? Cancer, heart disease, stroke… These things mostly occur in older people due to the aging process.
We tend to get through the first five or six decades of life relatively unscathed, from the point of view of health but, at some point, a kind of barrier appears to us: easy movements become difficult, we begin to lose hearing and sight. , frustrating and embarrassing things happen: the body that has worked tirelessly for years accumulates a huge number of aging or “senescent” cells.
It increases the decline of the immune system and the risk of dangerous cellular mutations, including the general wear and tear of all body structures, muscles and joints in the first place. For decades we are fine but then, suddenly, we stop or almost stop. Biogerontology research has accelerated over the past 30 years and recent successes are generating some enthusiasm. A 2015 study, published by the Mayo Clinic, in the United States, found that using a combination of existing drugs – DASATINIB, an anticancer medicine, and QUERCITIN – to remove senescent cells in mice “reversed a number of signs of aging, including improvement in heart function ”. A 2018 study with the same drugs found that the combination “slowed or reversed the aging process” in older mice. In another study, the drug spermidine extended the lifespan of mice by 10%, and studies using the drug rapamycin extended the health span of mice, worms and flies, albeit with side effects on the immune system. After the success in mice, the first trial to remove senescent cells in humans began in 2018 and others are underway.
Steele writes: “This collection of evidence is tempting and foreshadows a not-so-distant future where aging will be cured.”
Yes but when?
“Scientists are rightly skeptical but we will likely have a drug that treats aging in the next 10 years.” What Steele is talking about is not immortality; people will continue to die. Science doesn’t help if, looking at your phone, you go out on the street and get hit by a car. Or if you fall off a ladder and break your neck. Or if you are unfortunate enough to be hit by a missile in a war zone. Or if you contract a virulent infectious disease that does not have a vaccine. Steele expects that someday there will be many 150-year-olds around, as healthy as 20-year-olds. “The problem is that to say that we’re going to have 150-year-olds going around looking like 20-year-olds sounds like science fiction. Seems a little creepy. I wish those 150-year-olds didn’t have cancer, didn’t have severe heart disease or arthritis while still playing with their grandchildren and even their great-grandchildren. However, dealing with these things is a good way to make you re-evaluate our lifestyle. These days, Steele is running more than usual and has started watching what and how much he eats. “I’ve never been a huge couch potato,” he says. “But, in the same way, I tried to optimize things”. In the absence of anti-aging drugs, he suggests everyone to do the same. “It seems like a lot of the basic health tips that everyone can act out – get some exercise, don’t be overweight, try to eat a wide range of foods, don’t smoke – all of which basically slow down aging.”
Mythelor is a food supplement based on natural substances such as Quercetin, Fisetin, Oleuropein, ECGC and Selenium capable of modulating cellular immunity and senescence.
Cellular aging depends on non-modifiable genetic factors and epigenetic or environmental factors on which it is possible to intervene by making prevention. Advancing age and chronic diseases lead to an increase in senescent cells and the appearance of inflammatory processes that slow down cell turnover and reduce metabolic efficiency.
The components of Mythelor are able to counteract senescence by controlling inflammation and the production of free radicals (ROS). The constant use of Mythelor can help slow down the processes of cellular aging, alterations of mitochondrial DNA and the appearance of chronic diseases such as atherosclerosis, diabetes, Parkinson’s and Alzheimer’s. Mythelor modulates the immune response and reduces chronic antigenic stress, helping to protect the body from the risk of infectious, autoimmune and neoplastic diseases.