Lifespan, what it means and why it is important.


Lifespan, what it means and why it is important.

When talking about the average lifespan of living beings, the English term Lifespan is often used.

It is obvious that each of us wishes to increase the duration of our existence but this must not happen without paying the right attention to the quality of life itself.

Successful aging is determined by hereditary (genetic), epigenetic and lifestyle factors. If the former cannot be modified, it is possible to intervene on the other two through the prevention and care of our body.

How many times have we seen elderly people gradually lose their muscle reserves and live almost without energy, neglected from a nutritional point of view. Instead, it is possible to intervene on lifestyle, improve nutrition and integrate it with substances that activate anti-aging anabolic processes to help them live better and perhaps even longer. This is precisely the task of those who should take care of good health, prevention, aging and Lifespan.

One of the first issues to be addressed is the so-called state of “inflammaging”, ie low-grade inflammation that progresses inexorably with advancing age and with the appearance of any chronic disease.

The condition of inflammaging is characterized by a high concentration of C reactive protein and cytokines in the blood, including interleukins 6 (IL-6) and 8 (IL-8). The cause may be due to the accumulation of “misfolded” proteins, an alteration of intestinal permeability, a condition of obesity but also to a lower response of the killer lymphocytes responsible for the immune surveillance system.

If prevention is not done, over time there is a widespread accumulation, in every organ, of dead or senescent cells unable to reproduce due to excessive shortening of telomeres, damage to DNA and mitochondrial dysfunctions, etc. Senescent cells cause damage because they also have the ability to transform neighboring cells to which they spread inflammation. Research has shown that the elimination of senescent cells in elderly mice reverses the effects of aging and increases the lifespan in laboratory animals.

The new drugs and natural substances with geroprotective effects therefore aim to reduce oxidative stress and inflammation. Lately, the effects of Metformin (an antidiabetic drug) and some natural flavonoids such as quercetin or fisetin contained, not surprisingly, in the new Mythelor supplement are being studied.

Quercetin and fisetin have been included in this new supplement, but also other natural substances with an antioxidant and anti-inflammatory effect such as epigallocatechinagallate (ECGC) extracted from green tea, oleuropein present in olive oil and selenium, a trace mineral capable of strengthen the immune system. The advantage of taking Mythelor over any drug is closely linked to its effectiveness but above all to the wide margins of tolerability and safety of the substances used.